Anselm J. M. Hennis

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PURPOSE To evaluate risk factors for definite open-angle glaucoma (OAG), based on African-descent participants of the Barbados Eye Studies. DESIGN Cohort study with 81% to 85% participation over 9 years' follow-up. PARTICIPANTS We evaluated 3222 persons at risk, 40 to 84 years old, who did not have definite OAG at baseline. METHODS Participants had(More)
Stroke is a major health problem in Latin American and Caribbean countries. In this paper, we review the epidemiology, aetiology, and management of stroke in the region based on a systematic search of articles published in Spanish, Portuguese, and English. Stroke mortality is higher than in developed countries but rates are declining. Population-based(More)
Multiple breast cancer susceptibility loci have been identified in genome-wide association studies (GWAS) in populations of European and Asian ancestry using array chips optimized for populations of European ancestry. It is important to examine whether these loci are associated with breast cancer risk in women of African ancestry. We evaluated 25 single(More)
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268(More)
In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new(More)
The majority of genetic studies on open-angle glaucoma (OAG) have been conducted in primarily white populations, with investigations of inheritance patterns largely based on self-reported information. The Barbados Family Study of Open-Angle Glaucoma (BFSG) is the first study to investigate the transmission pattern(s) for OAG in a predominantly black(More)
OBJECTIVE To provide 9-year incidence estimates of age-related macular degeneration (AMD) in a population of African descent. DESIGN Population-based cohort study. PARTICIPANTS Two thousand seven hundred ninety-three participants (81% of eligible) after 9 years' follow-up. MAIN OUTCOME MEASURES Nine-year incidence of AMD-related features, based on(More)
OBJECTIVE To measure the 4-year risk of open-angle glaucoma (OAG) in a black population. DESIGN Population-based cohort study with 4 years of follow-up. SETTING Simple random sample of residents of Barbados, West Indies, aged 40 years or older. PARTICIPANTS A total of 3427 members of the cohort (85% of those eligible). MAIN OUTCOME MEASURE(More)
BACKGROUND The risk of open-angle glaucoma (OAG) may be related to low blood pressure (BP) relative to intraocular pressure (IOP), ie, to low perfusion pressure (PP). Alternatively, systemic hypertension may increase OAG risk. OBJECTIVE To clarify these possible relationships by evaluating hypertension and PP (where PP = BP - IOP) as risk factors for(More)
OBJECTIVE To estimate the 9-year incidence of diabetic retinopathy (DR) in a population with the same ancestry as African Americans. METHODS Participants with diabetes mellitus and gradable photographs at the 9-year examination were evaluated (n = 436). The incidences of minimum/moderate/severe DR, clinically significant macular edema (CSME), and(More)