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- Alberto Mantovani, Antonio Sica, Silvano Sozzani, Paola Allavena, Annunciata Vecchi, Massimo Locati
- Trends in immunology
- 2004
Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a,… (More)
- Cecilia Garlanda, Emilio Hirsch, +17 authors Alberto Mantovani
- Nature
- 2002
Pentraxins are a superfamily of conserved proteins that are characterized by a cyclic multimeric structure. The classical short pentraxins, C-reactive protein (CRP) and serum amyloid P component… (More)
- Silvia Bellocchio, Claudia Montagnoli, +7 authors Luigina Romani
- Journal of immunology
- 2004
In vitro studies have indicated the importance of Toll-like receptor (TLR) signaling in response to the fungal pathogens Candida albicans and Aspergillus fumigatus. However, the functional… (More)
- Antonio Sica, Alessandra Saccani, +4 authors Alberto Mantovani
- Journal of immunology
- 2000
IL-12 is a central cytokine in the activation of inflammation and immunity and in the generation of Th1-type responses. Tumor-associated macrophages (TAM) from mouse and human tumors showed defective… (More)
Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family.
- Cecilia Garlanda, Federica Riva, +9 authors Alberto Mantovani
- Proceedings of the National Academy of Sciences…
- 2004
TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling… (More)
- Annunciata Vecchi, Cecilia Garlanda, +7 authors Alberto Mantovani
- European journal of cell biology
- 1994
Two monoclonal antibodies (mAb), MEC 7.46 (IgG1) and MEC 13.3 (IgG2a) that specifically recognize mouse endothelial cells (EC) of blood vessels, were produced immunizing a Lewis rat with a polyoma… (More)
- Nicola Di Gaetano, Elena Cittera, +6 authors Josée Golay
- Journal of immunology
- 2003
Rituximab is an anti-CD20 chimeric mAb effective for the treatment of B-NHL. It can lyse lymphoma cells in vitro through both C- and Ab-dependent cellular cytotoxicity. The mechanism of action of… (More)
- Alberto Mantovani, Paola Allavena, Silvano Sozzani, Annunciata Vecchi, Massimo Locati, Antonio Sica
- Seminars in cancer biology
- 2004
Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are… (More)
- Federica Marchesi, Paolo Monti, +5 authors Paola Allavena
- Cancer research
- 2004
In this study, we have evaluated 11 pancreatic tumor cell lines and tumor cells from surgical samples of patients with pancreatic adenocarcinoma for expression of the chemokine receptor CXCR4. Six of… (More)
- William Vermi, Elena Riboldi, +12 authors Silvano Sozzani
- The Journal of experimental medicine
- 2005
Chemerin is a chemotactic agent that was recently identified as the ligand of ChemR23, a serpentine receptor expressed by activated macrophages and monocyte-derived dendritic cells (DCs). This paper… (More)