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Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma
Although both Mcl-1 and Bcl-xL keep proapoptotic Bak in check, it is the loss of Mcl-1 that sensitizes cells to death receptor–mediated apoptosis.
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MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.
BACKGROUND The predictive value of microRNAs (miRNAs) in tumour cells and infiltrating immune cells for the efficacy of chemoradiation (CRTX) in locally advanced head and neck squamous cell carcinomaExpand
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p14ARF-induced Apoptosis in p53 Protein-deficient Cells Is Mediated by BH3-only Protein-independent Derepression of Bak Protein through Down-regulation of Mcl-1 and Bcl-xL Proteins
Background: P14ARF is capable of triggering p53/Bax-independent mitochondrial apoptosis. Results: Expression of p14ARF in p53/Bax-deficient cells causes the deprivation of anti-apoptotic Mcl-1 andExpand
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Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3
Induction of cell death by p14ARF is mediated through a Bax/Bak-dependent mitochondrial apoptosis pathway. To investigate the upstream signaling events required for the activation of Bax and/or BakExpand
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p14ARF induces apoptosis via an entirely caspase‐3‐dependent mitochondrial amplification loop
The p14ARF tumor suppressor triggers cell death or cell cycle arrest upon oncogenic stress. In MCF‐7 breast carcinoma cells, expression of the tumor suppressor gene p14ARF fails to trigger apoptosisExpand
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Nijmegen breakage syndrome (NBS) due to maternal isodisomy of chromosome 8
Raymonda Varon,* Annika Müer, Klaus Wagner, Hannelore Zierler, Sigrun Sodia, Ludwig Rauter, Erwin Petek, Holger Tönnies, Haidemarie Neitzel, Karl Sperling, and Peter M. Kroisel Institute of HumanExpand
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50 Influence of microRNA expression profiles on the efficacy of radiochemotherapy in locally advanced head and neck squamous cell carcinoma
Introduction Despite recent advances in radiochemotherapy, the treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) is still challenging with 5-year survival rates less thanExpand