Annika Jahn

  • Citations Per Year
Learn More
Everolimus (EVL) is widely used in solid organ transplantation. It is known to have antiproliferative and immunosuppressive abilities via inhibition of the mTOR pathway. Preventive EVL administration may lower inflammation induced by cardiopulmonary bypass (CPB) and reduce systemic inflammatory response syndrome (SIRS). After oral loading with EVL 2.5(More)
Introduction: Although levosimendan is commonly used, recent clinical trials remain ambiguous. Extra-corporeal circulation induces Ischemia/Reperfusion Injury (IRI) and inflammation. Methods: In our study, male rats (400-500 g) were cannulated, intravenously treated with 12 μg/kg body weight levosimendan (n = 4) or vehicle solution (n = 5) and connected to(More)
OBJECTIVES Cardiac surgery with cardiopulmonary bypass (CPB) provokes ischaemia and reperfusion injury (IRI). Superoxide is a main mediator of IRI and is detoxified by superoxide dismutases (SODs). Extracellular SOD (SOD3) is the prevailing isoform in the cardiovascular system. Its mutation is associated with elevated risk for ischaemic heart disease as(More)
Lignin is a major component of plant material and is the most abundant renewable source of aromatic polymer in nature [1]. At present it is typically treated as “waste” in paper and biofuel production. A promising alternative is the use of lignin as feedstock for aromatic base chemicals. The aim of the work was to provide access to this class of compounds(More)
Introduction: Although levosimendan is commonly used, recent clinical trials remain ambiguous. Extra-corporeal circulation induces Ischemia/Reperfusion Injury (IRI) and inflammation. Methods: In our study, male rats (400-500 g) were cannulated, intravenously treated with 12 μg/kg body weight levosimendan (n = 4) or vehicle solution (n = 5) and connected to(More)
  • 1