Annie On

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We studied the penetration characteristics of lomefloxacin in bone in 30 patients with osteoarthritis undergoing total hip replacement. Patients were given a single oral 400 mg dose at various times from 1 to 12 hours prior to removal of bone samples. The peak plasma and bone (subchondral bone from femoral head) concentrations reached approximately 4.0(More)
  • A On
  • 1990
AP has been shown to be a promising alternative therapy to trimethroprim-sulfamethoxazole for the treatment and prevention of PCP in AIDS patients with fewer side effects than the systemic agents. More controlled clinical trials are still needed to establish the optimal dosage regimen for treatment and prevention of PCP. Clinicians should also be aware that(More)
This document reflects emerging clinical and scientific advances on the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Local institutions can dictate amendments to these opinions. They should be well documented if modified at the local level. None of(More)
  • Alon Shrim, Montreal Qc, +33 authors J Obstet Gynaecol
  • 2012
This document reflects emerging clinical and scientific advances on the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. local institutions can dictate amendments to these opinions. They should be well documented if modified at the local level. None of(More)
Streamlining antibiotic therapy--ie, simplifying regimens, route of administration, or both--is necessary in the modern treatment of hospitalized patients with infectious diseases. Due to their pharmacokinetic profiles and comparative efficacy and safety, the quinolone class of antibiotics is an ideal class for which to direct streamlining efforts.(More)
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