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Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus
The highly specific organization of the olfactory bulb (OB) is well known, but the impact of early odorant experience on its circuit structure is unclear. Olfactory sensory neurons (OSNs) projectExpand
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Balanced Synaptic Impact via Distance-Dependent Synapse Distribution and Complementary Expression of AMPARs and NMDARs in Hippocampal Dendrites
Neuronal computation involves the integration of synaptic inputs that are often distributed over expansive dendritic trees, suggesting the need for compensatory mechanisms that enable spatiallyExpand
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Olfactory Bulb Deep Short-Axon Cells Mediate Widespread Inhibition of Tufted Cell Apical Dendrites
In the main olfactory bulb (MOB), the first station of sensory processing in the olfactory system, GABAergic interneuron signaling shapes principal neuron activity to regulate olfaction. However, aExpand
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Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb
Abstract Early sensory experience shapes the anatomy and function of sensory circuits. In the mouse olfactory bulb (OB), prenatal and early postnatal odorant exposure through odorized foodExpand
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Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase
Human lung adenocarcinoma exhibits a propensity for de-differentiation, complicating diagnosis and treatment, and predicting poorer patient survival. In genetically engineered mouse models of lungExpand
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The osteogenic potential of the neural crest lineage may contribute to craniosynostosis
The craniofacial skeleton is formed from the neural crest and mesodermal lineages, both of which contribute mesenchymal precursors during formation of the skull bones. The large majority of cranialExpand
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Mouse Navigation Strategies for Odor Source Localization
We used an open field odor-based spot-finding task indoors with little wind, examining navigation strategies as mice search for and approach an odor source. Expand
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