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—We present a distributed proximal-gradient method for optimizing the average of convex functions, each of which is the private local objective of an agent in a network with time-varying topology. The local objectives have distinct differentiable components, but they share a common nondifferentiable component, which has a favorable structure suitable for(More)
Hsp104, a protein disaggregase from yeast, can be engineered and potentiated to counter TDP-43, FUS, or α-synuclein misfolding and toxicity implicated in neurodegenerative disease. Here, we reveal that extraordinarily disparate mutations potentiate Hsp104. Remarkably, diverse single missense mutations at 20 different positions interspersed throughout the(More)
In chronic infections, pathogens are often in the presence of other microbial species. For example, Pseudomonas aeruginosa is a common and detrimental lung pathogen in individuals with cystic fibrosis (CF) and co-infections with Candida albicans are common. Here, we show that P. aeruginosa biofilm formation and phenazine production were strongly influenced(More)
  • T M K Roeder, P I Frazier, R Szechtman, E Zhou, T Huschka, S E Chick +3 others
  • 2016
We study a simulation optimization approach for the online-retail inventory replenishment problem, where the goal is to minimize the total operational cost among a class of parametrized replenishment policies. We model the problem as an infinite-horizon average-cost dynamic program with discrete states and controls, which can be difficult to solve due to(More)
Antimicrobial peptides are an important component of the molecular arsenal employed by hosts against bacteria. Many bacteria in turn possess pathways that provide protection against these compounds. In Escherichia coli and related bacteria, the PhoQ/PhoP signalling system is a key regulator of this antimicrobial peptide defence. Here we show that treating(More)
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