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HoxA genes exhibit central roles during development and causal mutations have been found in several human syndromes including limb malformation. Despite their importance, information on how these genes are regulated is lacking. Here, we report on the first identification of bona fide transcriptional enhancers controlling HoxA genes in developing limbs and(More)
Limb development relies on an exquisite coordination between growth and patterning, but the underlying mechanisms remain elusive. Anterior-posterior and proximal-distal specification initiates in early limb bud concomitantly with the proliferative expansion of limb cells. Previous studies have shown that limb bud growth initially relies on fibroblast growth(More)
Obstruction of a major bronchus by a benign lesion can be accompanied by a functional reduction of the perfusion of the distal lung. This disorder is reversible after removal of the obstruction. We present 5 cases of obstruction of a main bronchus with functional exclusion of the affected lung on scintigraphy. The obstructing lesion was carcinoid tumour in(More)
In this study, a "green chemistry" approach was developed as an option for remediation of toxic mercury in the environment. Twenty mercury compounds were treated with an environmentally friendly agent cyclodextrin to produce stable non-toxic mercury in soil and water. The binding efficiency was determined using high performance liquid chromatography with(More)
Podocytes are specialized kidney cells that form the kidney filtration barrier through the connection of their foot processes. Nephrin and Neph family transmembrane molecules at the surface of podocytes interconnect to form a unique type of cell-cell junction, the slit diaphragm, which acts as a molecular sieve. The cytoplasmic tails of Nephrin and Neph(More)
The authors studied 13 cases of arrhythmia following pneumonectomy in a series of 94 pneumonectomies performed in the Thoracic Surgery Unit. The arrhythmias essentially consisted of atrial fibrillation which was well tolerated haemodynamically. It generally occurred in ambulant patients on about the 5th postoperative day. These arrhythmias responded well to(More)
The authors describe a technique for re-establishing tracheal continuity after anastomotic resection of the cervical and cervico-thoracic trachea. Simply lowering the larynx cervically without an associated thoracic phase enables termino-terminal anastomosis of the trachea to be carried out after resection of more than 5 cm. In this article, the technique(More)
Resection and anastomosis of the trachea or the tracheal bifurcation, raises numerous problems, which will be discussed in a series of 81 patients: -there is more or less marked ventilatory insufficiency related to the degree of the stenosis, and difficulties of expectoration responsible for retention of sputum; -per-operative ventilation. One must choose(More)
Having first recalled the problems involved in classifying impulsion phobias, (problems which have been experienced in the course of all the work done on this subject), the authors report, from a strictly clinical viewpoint, on a series of studies of patients whose problems are very different but who all show the symptoms of impulsion phobia. They next(More)