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The etiology of the nigrostriatal pathway degeneration in Parkinson's disease (PD) is unknown but there is a growing pool of evidence that environmental factors may be involved in the genesis of this disorder. The discovery of the N-Methyl 4-Phenyl 1,2,3,6-Tetrahydro-Pyridine (MPTP)-induced injury in late 1970s provided the first experimental model of PD(More)
BACKGROUND Epidemiological surveillance of Creutzfeldt-Jakob disease (CJD) was reinstituted in the UK in 1990 to identify any changes in the occurrence of this disease after the epidemic of bovine spongiform encephalopathy (BSE) in cattle. METHODS Case ascertainment of CJD was mostly by direct referral from neurologists and neuropathologists. Death(More)
BACKGROUND An international study of the epidemiologic characteristics of Creutzfeldt-Jakob disease (CJD) was established in 1993 and included national registries in France, Germany, Italy, the Netherlands, Slovakia, and the United Kingdom. In 1997, the study was extended to Australia, Austria, Canada, Spain, and Switzerland. METHODS Data were pooled from(More)
We investigated the prevalence of Parkinson's disease in a representative sample of the elderly population living in the Gironde département, France. Among 3149 people over age 65, the prevalence ratio for Parkinson's disease was 1.4%, without significant difference between men and women. We found that age-specific prevalence ratios increased with age from(More)
A population-based study of the prevalence and risk factors of multiple sclerosis (MS) was conducted in the Hautes-Pyrénées, the southwestern region of France. The prevalence rate per 100,000 was equal to 40. Data on the past medical history of 63 MS patients and matched controls were collected. The frequency and age at occurrence of common childhood(More)
A collaborative study of human transmissible spongiform encephalopathies has been carried out from 1993 to 2000 and includes data from 10 national registries, the majority in Western Europe. In this study, we present analyses of predictors of survival in sporadic (n = 2304), iatrogenic (n = 106) and variant Creutzfeldt-Jakob disease (n = 86) and in cases(More)
After the occurrence of bovine spongiform encephalopathy (BSE), there has been concern that transmission of BSE to the human population might result in a change in the epidemiological characteristics of Creutzfeldt-Jakob disease (CJD). A collaborative study of CJD in the European Union was performed from 1993 to 1995, to compare data from national(More)
4912 deaths related to multiple sclerosis have been identified in France during the period 1968-1977. The average annual death rate was equal to 0.96 per 100,000 population. Analysis showed a clear south to north increasing gradient. The study failed to find any geographic difference from data concerning 5173 amyotrophic lateral sclerosis (ALS) deaths which(More)