Anni Virtanen

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High coverage and attendance is essential for cervical cancer screening success. We investigated whether the previous positive experiences on increasing screening attendance by self-sampling in Finland are sampler device dependent. All women identified to cervical cancer screening in 2013 in 28 Finnish municipalities were randomised to receive a lavage- (n(More)
BACKGROUND Offering self-sampling to non-attendees of cervical screening increases screening attendance. METHODS We used observations from two Finnish studies on the use of self-sampling among the non-attendees to estimate in a hypothetical screening population of 100,000 women the possible costs per extra screened woman and costs per extra detected and(More)
Alzheimer's disease (AD) is the most common cause of dementia and one of the leading sources of morbidity and mortality in the aging population wordwide. As the population ages, the incidence of this neurodegenerative disease will increase, and it will pose a major socio-economical challenge to all societies in the future. There is a prolonged(More)
spectra are dependent on the chemical environment around the nuclei, making NMR spectroscopy a powerful method for studying molecular structure and dynamics at the atomic level. The possibility to predict the spectral parameters from known or proposed molecular structures can be exploited in different applications. This thesis presents two NMR parameter(More)
Epidemiologic Follow-up Study in Middle-aged Finnish Men SANNA RANTAKÖMI Alcohol consumption, atherosclerosis and stroke Epidemiologic follow-up study in middle-aged Finnish men To be presented by permission of the IV V Rantakömi, Sanna. Alcohol consumption, atherosclerosis and stroke. Epidemiologic follow-up study in middle-aged Finnish men. ABSTRACT(More)
Alpha-synuclein (α-syn) is a protein that becomes aggregated into Lewy bodies and other insoluble inclusions in Parkinson's disease and some other neurodegenerative diseases. Its expression is increased also in drug addiction. The principal physiological function of the protein appears to be regulation of synaptic dopamine (DA) signaling in the brain, but(More)
IV V Huttunen Joanna A study of rodent brain function with functional and pharmacological magnetic resonance imaging ABSTRACT It has been known for more than a century that stimulus induced neuronal activation evokes changes in the vascular system. During neuronal activation, the blood flow increase exceeds blood demand, and the amount of deoxygenated(More)
Cytochrome P450 (CYP) enzymes are important enzymes involved in drug metabolism. The CYP enzymes are a family of heme proteins involved in the metabolism of numerous toxic and pharmacologically active compounds and can cause drug-drug-interactions with co-administered drugs as well as unwanted adverse side effects. Several in vitro methods have been(More)
Transcranial Magnetic Stimulation (TMS) can be used to assess corticospinal, cortico-cortical and cortico-subcortical network physiology and function. In the motor system, TMS-induced cortical activation leads to peripheral muscle responses. Various motor functions can be characterized extensively by applying specific stimulation protocols. However, the(More)