Annette P. M. van den Elzen

Learn More
BACKGROUND Light-to-moderate alcohol consumption has been associated with a lower risk of cardiovascular disease. The protective effect of alcohol could involve arterial properties as arterial stiffness and distensibility. METHODS The relationship between alcohol and arterial stiffness was studied within the framework of the Rotterdam Study, a(More)
OBJECTIVE To examine the associations of maternal smoking in pregnancy with development of cholesterol levels from childhood to adulthood. METHODS Total cholesterol, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were measured annually from 1975 to 1993 and in 2002 in 350 subjects aged 5-19 years at baseline who(More)
Although screening for child abuse at emergency departments (EDs) increases the detection rate of potential child abuse, an accurate instrument is lacking. This study was designed to measure the accuracy of a screening instrument for detection of potential child abuse used in EDs. In a prospective cohort study at three Dutch EDs, a 6-item screening(More)
BACKGROUND Previous studies on familial aggregation of blood pressure (BP) have reported data on family history of hypertension. Data on actual parental BP levels and the subsequent natural history of BP in their offspring are scarce. METHODS In a population-based study with 596 children aged 5 to 19 years, cardiovascular risk factors were measured(More)
OBJECTIVE Although systematic screening for child abuse of children presenting at emergency departments might increase the detection rate, studies to support this are scarce. This study investigates whether introducing screening, and training of emergency department nurses, increases the detection rate of child abuse. METHODS In an intervention cohort(More)
BACKGROUND A U- or J-shaped association exists between alcohol consumption and coronary heart disease. One of the proposed mechanisms for this association involves atherogenesis, but there are no data on the association between alcohol consumption and coronary atherosclerosis in asymptomatic subjects. Coronary calcification, a measure of coronary(More)
In order to elucidate critical points concerning Listeria monocytogenes during bovine and porcine slaughter, cutting and processing, 843 samples were obtained from carcasses, primal cuts, products at retail and from environmental surfaces. Only 2-7% of the carcasses and 0-10% of the environmental samples in the 'clean' part of the pork slaughterline were(More)
BACKGROUND Moderate alcohol consumption has been shown to protect against cardiovascular disease. Aortic stiffness can be regarded as a marker of cardiovascular disease risk. Previously we have shown an inverse to J-shaped association between alcohol intake and aortic stiffness in middle-aged and elderly men and postmenopausal women. OBJECTIVE In the(More)
During slaughtering of animals and subsequent meat processing the process water used becomes polluted with organic matter of animal origin (i.e. protein and fat). This organic sludge is, in principle, a product suitable for animal feeding. To investigate the microbiological contamination level of sludge, raw sludge was collected at pig (n = 8) and poultry(More)
We present the first two reported unrelated patients with an isolated sedoheptulokinase (SHPK) deficiency. The first patient presented with neonatal cholestasis, hypoglycemia, and anemia, while the second patient presented with congenital arthrogryposis multiplex, multiple contractures, and dysmorphisms. Both patients had elevated excretion of erythritol(More)