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Antioxidant and Anti-Inflammatory Activities of Barettin
In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in… Expand
Rationally designed ligands for asymmetric iridium-catalyzed hydrogenation of olefins.
- K. Källström, C. Hedberg, P. Brandt, Annette Bayer, P. Andersson
- Chemistry, Medicine
- Journal of the American Chemical Society
- 13 October 2004
A new class of chiral N,P-ligands for the Ir-catalyzed asymmetric hydrogenation of aryl alkenes has been developed. These new ligands proved to be highly efficient and tolerates a broad range of… Expand
Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.
- Susann Skagseth, Sundus Akhter, +5 authors Annette Bayer
- Chemistry, Medicine
- European journal of medicinal chemistry
- 28 July 2017
Bacterial resistance is compromising the use of β-lactam antibiotics including carbapenems. The main resistance mechanism against β-lactams is hydrolysis of the β-lactam ring mediated by serine- or… Expand
Synthesis of Indoles and Pyrroles Utilizing Iridium Carbenes Generated from Sulfoxonium Ylides.
Metal carbenes can undergo a myriad of synthetic transformations. Sulfur ylides are potential safe precursors of metal carbenes. Herein, we report cascade reactions that involve carbenoids derived… Expand
Rationally Designed Ligands for Asymmetric Iridium-Catalyzed Hydrogenation of Olefins.
On the Mechanism of Iridium-Catalyzed Asymmetric Hydrogenation of Imines and Alkenes: A Theoretical Study
Phosphine-oxazoline (PHOX)-based iridium complexes have emerged as useful tools for enantioselective hydrogenation of unfunctionalized alkenes and imines. The mechanistic details of the asymmetric… Expand
Enantioselective imine hydrogenation with iridium-catalysts: Reactions, mechanisms and stereocontrol
Abstract This review summarizes the current status of knowledge on asymmetric iridium-catalyzed direct hydrogenations of acyclic and cyclic imines. An overview of the most interesting catalysts with… Expand
Enantioselective Incorporation of CO2: Status and Potential
CO2 is a promising and sustainable carbon feedstock for organic synthesis. New catalytic protocols for efficient incorporation of CO2 into organic molecules are continuously being reported. However,… Expand
Catalytic Asymmetric Hetero Diels–Alder Reactions of N‐Sulfinyl Dienophiles with Chiral Bis(oxazoline)copper(II) and ‐zinc(II) Triflates
Asymmetric hetero Diels–Alder (HDA) reactions of N-sulfinyldienophiles with bis(oxazoline)copper(II) and -zinc(II) triflatesare described. The cycloaddition with cyclic and acyclic 1,3-dienes has… Expand
Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening.
- B. Lund, T. Christopeit, Yngve Guttormsen, Annette Bayer, H. Leiros
- Medicine, Chemistry
- Journal of medicinal chemistry
- 20 May 2016
The spread of antibiotic resistant bacteria is a global threat that shakes the foundations of modern healthcare. β-Lactamases are enzymes that confer resistance to β-lactam antibiotics in bacteria,… Expand