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Sickle cell disease (SCD) does not occur in the indigenous German population. However, with the increasing numbers of immigrants its prevalence is steadily rising. Nevertheless, robust epidemiological data is not available for Germany and, consequently, the German newborn screening (NBS) program does not include SCD. Between 1 September 2011 and 30 November… (More)
Sickle cell disease (SCD) does not occur in the indigenous German population, but with the increasing number of immigrants from countries at high risk for hemoglobinopathies, the question emerges whether or not a newborn screening program (NBS) for SCD disease should be initiated in Germany anyhow. We have recently shown that in Berlin, a city with a very… (More)
In ageing female subjects, the urinary noradrenaline excretion (UNA) is reduced with respect to the controls in young adults. On the other hand the ratio UNA/clearance of endogenous creatinine increases with ageing. This provides a confirmation of the fact that ageing is associated with an increase in plasma noradrenaline. The ratio UA/clearance of… (More)
In normal subjects in basal conditions, urinary excretion of noradrenaline is directly related to the hydrostatic pressure changes induced by the body posture in the dependant parts of the venous system. Adrenaline elimination is no influenced by these factors.