Annemari Uusimäki

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This study was aimed at assessing the adequacy of a random capillary whole blood glucose (RCBG) test as a screening test for diabetes mellitus in a middle-aged (55-year-old) Finnish population. Both the screening test (RCBG) and a standard 2-h oral glucose tolerance test (OGTT) were performed on all the participants according to the WHO criteria. The(More)
The prevalence of depression, measured as high rates of depressive symptoms (Zung Self-Rating Depression Scale), was studied in a 55-year-old Finnish population consisting of all persons born in 1935 and living in the city of Oulu on 1 October 1990, who were alive at the beginning of the study (n = 1008). Of these, 345 men (76%) and 435 women (79%)(More)
The relationships between depression, measured as high rates of depressive symptoms (Zung Self-Rating Depression Scale, ZSDS), and musculoskeletal pains (Kuorinka et al. 1987) were described in a 55-year-old Finnish population consisting of all the 1008 persons born in 1935 and living in the city of Oulu on 1 October 1990. Three hundred forty-five men (76%)(More)
OBJECTIVE To describe the prevalence of previously diagnosed and undiagnosed diabetes and impaired glucose tolerance (IGT) by sex, marital status, employment, exercise behaviour, and body mass index (BMI), and to compare previously diagnosed and undiagnosed diabetic patients. DESIGN A survey of the total 55-year-old population living in a Finnish city on(More)
Among 183 middle-aged Finnish subjects with impaired glucose tolerance (IGT) defined according to the 1985 World Health Organization (WHO) criteria) who were retested on average 2.1 years after the first examination, diabetes developed in 14 (7.7%), persistent IGT in 54 (29.5%), and IGT was transient in 115 (62.8%). The odds ratio for diabetes was 4.4 (95%(More)
Proprotein convertase subtilisin/kexin (PCSK) enzymes convert proproteins into bioactive end products. Although other PCSK enzymes are known to be essential for biological processes ranging from cholesterol metabolism to host defense, the in vivo importance of the evolutionarily ancient PCSK7 has remained enigmatic. Here, we quantified the expressions of(More)
Small nucleolar RNAs (snoRNAs) direct sequence-specific modifications to ribosomal RNA. We hypothesized that the expression of snoRNAs may be altered in leukemic cells. The expression of snoRNAs was analyzed in various leukemic cell lines by massive parallel sequencing (SOLiD). Quantitative real-time PCR (RT-qPCR) was used to validate the expression(More)
To identify the early diabetic musculoskeletal symptoms of previously undiagnosed diabetic subjects, a case-control study was carried out. The cases and controls were recruited from a population aged 55 years. Questions concerning the symptoms were asked before the 2-h oral glucose tolerance tests (OGTT). The results show that pain in the right hand was the(More)
The Sin3A-associated proteins SAP30 and SAP30L share 70% sequence identity and are part of the multiprotein Sin3A corepressor complex. They participate in gene repression events by linking members of the complex and stabilizing interactions among the protein members as well as between proteins and DNA. While most organisms have both SAP30 and SAP30L, the(More)
The purpose of the present study was to describe the associations between long-term disorders of musculoskeletal system and work career in elderly workers. The data were obtained by a postal questionnaire and clinical examinations. The study group consisted of 778 elderly urban persons, who were 55 years old and who lived in the city of Oulu in northern(More)