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Management of hot flashes in patients who have breast cancer with venlafaxine and clonidine: a randomized, double-blind, placebo-controlled trial.

• Annelies H. Boekhout, A. de Saint Vincent, +7 authors Jan H. M. Schellens
• Journal of clinical oncology : official journal…
• 2011

PURPOSE Therapies for breast cancer may induce hot flashes that can affect quality of life. We undertook a double-blind, placebo-controlled trial with the primary objective of comparing the average… (More)

Symptoms and treatment in cancer therapy-induced early menopause.

• Annelies H. Boekhout, Jos H. Beijnen, Jan H. M. Schellens
• The oncologist
• 2006

Young women with breast cancer often experience early menopause as a result of the therapy for their malignant disease. The sudden occurrence of menopause resulting from chemotherapy, oophorectomy,… (More)

Population pharmacokinetic-pharmacodynamic analysis of trastuzumab-associated cardiotoxicity.

• J. G. Coen van Hasselt, Annelies H. Boekhout, Jos H. Beijnen, J. H. M. Schellens, A. D. R. Huitema
• Clinical pharmacology and therapeutics
• 2011

Trastuzumab treatment is associated with cardiac dysfunction. The aim of this study was to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model for the relationship between left… (More)

Angiotensin II-Receptor Inhibition With Candesartan to Prevent Trastuzumab-Related Cardiotoxic Effects in Patients With Early Breast Cancer: A Randomized Clinical Trial.

• Annelies H. Boekhout, Jourik A. Gietema, +18 authors Jan H. M. Schellens
• JAMA oncology
• 2016

IMPORTANCE This is the first randomized placebo-controlled evaluation of a medical intervention for the prevention of trastuzumab-related cardiotoxic effects. OBJECTIVE To determine as the primary… (More)

Trastuzumab.

• Annelies H. Boekhout, Jos H. Beijnen, Jan H. M. Schellens
• The oncologist
• 2011

Trastuzumab is standard of care in the treatment of human epidermal growth factor receptor (HER)-2⁺ early and advanced breast cancer. Recently, it has been approved for the treatment of HER-2⁺… (More)

Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens

• Aurelia H. M. de Vries Schultink, Annelies H. Boekhout, +5 authors Alwin D. R. Huitema
• Journal of Pharmacokinetics and Pharmacodynamics
• 2018

Trastuzumab is associated with cardiotoxicity, manifesting as a decrease of the left-ventricular ejection fraction (LVEF). Administration of anthracyclines prior to trastuzumab increases risk of… (More)

Large-scale fast-track diagnostics in a comprehensive cancer center.

• Wim H van Harten, Nicolette Goedbloed, Marja van Wijngaarden, Arthur Dernison, Annelies H. Boekhout
• Journal of clinical oncology : official journal…
• 2013

185 Background: In general, patients with a cancer suspicion visit the hospital multiple times before the diagnosis is completed. Using various "operations management" techniques a limited number of… (More)

I-123-MIBG myocardial imaging in trastuzumab-based cardiotoxicity: the first experience.

• Marcel P M Stokkel, Linda J de Wit-van der Veen, Annelies H. Boekhout
• Nuclear medicine communications
• 2013

INTRODUCTION Cardiotoxicity related to trastuzumab anticancer treatment poses a diagnostic challenge at early stages. The aim of the present pilot study was to assess the value of… (More)

Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline…

• Roderick Skinner, Renée L. Mulder, +22 authors Daniel M Green
• The Lancet. Oncology
• 2017

Treatment with chemotherapy, radiotherapy, or surgery that involves reproductive organs can cause impaired spermatogenesis, testosterone deficiency, and physical sexual dysfunction in male pubertal,… (More)

A survivorship care plan for breast cancer survivors: extended results of a randomized clinical trial.

• Annelies H. Boekhout, Elizabeth Maunsell, +4 authors Eva Grunfeld
• Journal of cancer survivorship : research and…
• 2015

PURPOSE Prevailing wisdom suggests that implementation of a survivorship care plan (SCP) will address deficits in survivorship care planning and delivery for cancer patients. Here, we present… (More)

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