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1. The gated membrane currents (a tetrodotoxin-sensitive Na+ current and a tetraethylammonium- and 4-aminopyridine-sensitive K+ current) of the rapidly adapting stretch receptor neurone of lobster were investigated with respect to their kinetic properties using electrophysiological, pharmacological, and mathematical techniques. 2. The currents were found to(More)
1. A polarization-induced membrane current, IQ, was investigated in the slowly adapting lobster stretch receptor neurone using conventional electrophysiological techniques including intracellular ion measurements. 2. The current was readily blocked by Cs+ in a voltage-dependent manner, but proved to be unaffected by tetrodotoxin, tetraethylammonium and(More)
We propose a software architecture for user-cooperative systems, like knowledge systems. This architecture incorporates important notions for building up a context, such as cooperation, explanations and incremental knowledge acquisition. Our main concern in this paper is representation methodology. We show that the architecture can be realized as a pure(More)
The transmembrane exchange of Na+, K+, and Cl- in slowly and rapidly adapting lobster stretch receptor neurones was studied using ion-sensitive microelectrodes in combination with conventional electrophysiological techniques. The investigation was founded on the assumption that the transmembrane ion exchange is accomplished by active and passive transports(More)
Verification of knowledge-bases is a critical step to ensure the quality of a knowledge-based system. The success of these systems depends heavily on how qualitative the knowledge is. Manual verification is however cumbersome and error prone, especially for large knowledge-bases. This thesis provides a design theory, based upon the suggested framework by(More)