Anneke M Knetsch

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AIMS To determine the prevalence, incidence rate, lifetime risk and prognosis of heart failure. METHODS AND RESULTS The Rotterdam Study is a prospective population-based cohort study in 7983 participants aged > or =55. Heart failure was defined according to criteria of the European Society of Cardiology. Prevalence was higher in men and increased with age(More)
BACKGROUND Experimental studies have shown that the known biologic effects of proinflammatory cytokines could explain many aspects of the syndrome of heart failure. The inflammatory marker that presently seems most suitable to assess inflammation is C-reactive protein (CRP). This study was designed to investigate the association between serum CRP levels, as(More)
OBJECTIVE To investigate whether arterial stiffening, one of the characteristics of the aging vascular system, is associated with orthostatic hypotension. DESIGN Cross-sectional data of a cohort study in elderly men and women. PARTICIPANTS We investigated the relationship between arterial stiffness and orthostatic hypotension within the framework of the(More)
AIMS Evidence is accumulating that inflammation plays a role in the pathophysiology of heart failure. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has pro-inflammatory properties. We investigated whether Lp-PLA2 activity is associated with heart failure. METHODS AND RESULTS Lp-PLA2 activity was determined in a random sample of 1820 subjects from the(More)
Plasma photocathode wakefield acceleration combines energy gains of tens of GeV m-1 with generation of ultralow emittance electron bunches, and opens a path towards 5D-brightness orders of magnitude larger than state-of-the-art. This holds great promise for compact accelerator building blocks and advanced light sources. However, an intrinsic by-product of(More)