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BACKGROUND Lung cancer has the highest mortality of all cancers. The aim of this study was to examine DNA hypermethylation in sputum and validate its diagnostic accuracy for lung cancer. METHODS DNA hypermethylation of RASSF1A, APC, cytoglobin, 3OST2, PRDM14, FAM19A4 and PHACTR3 was analysed in sputum samples from symptomatic lung cancer patients and(More)
OBJECTIVES To establish the safety of an intranasal diamorphine (IND) spray in children. DESIGN An open-label, single-dose pharmacovigilance trial. SETTING Emergency departments in eight UK hospitals. PARTICIPANTS Children aged 2-16 years with a fracture or other trauma. OUTCOME MEASURES Adverse events (AE) specifically related to nasal irritation,(More)
INTRODUCTION Although sexual side effects are a common reason for noncompliance with medication, information on impairment of sexuality in psychiatric inpatients is scarce. METHODS In the present multi-center study, data on several aspects of sexual functioning were collected in psychiatric inpatients using a previously validated questionnaire. RESULTS(More)
INTRODUCTION Sexual dysfunction is a common side effect of antipsychotic medication. Although increased prolactin levels caused by antipsychotic agents are believed to play a major role with regard to sexual side effects, the underlying mechanism of antipsychotic agent-induced sexual dysfunction remains poorly understood. METHODS In a multicentric study(More)
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