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Extracellular α-Synuclein has been implicated in interneuronal propagation of disease pathology in Parkinson's Disease. How α-Synuclein is released into the extracellular space is still unclear. Here, we show that α-Synuclein is present in extracellular vesicles in the central nervous system. We find that sorting of α-Synuclein in extracellular vesicles is(More)
Extracellular α-synuclein has been proposed as a crucial mechanism for induction of pathological aggregate formation in previously healthy cells. In vitro, extracellular α-synuclein is partially associated with exosomal vesicles. Recently, we have provided evidence that exosomal α-synuclein is present in the central nervous system in vivo. We hypothesized(More)
Extracellular a-synuclein has been proposed as a crucial mechanism for induction of pathological aggregate formation in previously healthy cells. In vitro, extracellular a-synuclein is partially associated with exosomal vesicles. Recently, we have provided evidence that exosomal a-synuclein is present in the central nervous system in vivo. We hypothesized(More)
Extracellular a-synuclein has been proposed as a crucial mechanism for induction of pathological aggregate formation in previously healthy cells. In vitro, extracellular a-synuclein is partially associated with exosomal vesicles. Recently, we have provided evidence that exosomal a-synuclein is present in the central nervous system in vivo. We hypothesized(More)
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