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Tumor Suppressor NF2 Blocks Cellular Migration by Inhibiting Ectodomain Cleavage of CD44
Ectodomain cleavage (shedding) of transmembrane proteins by metalloproteases (MMP) generates numerous essential signaling molecules, but its regulation is not totally understood. CD44, a cleavedExpand
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  • 1
Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization*♦
Background: Intracellular domain (ICD) modifications regulate extracellular ectodomain cleavage by metalloproteases. How this inside-out signal is relayed is unknown. Results: Cleavage requiresExpand
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1 TUMOR SUPPRESSOR NF 2 BLOCKS CELLULAR MIGRATION BY INHIBITING ECTODOMAIN CLEAVAGE OF CD 44
Ectodomain cleavage (shedding) of transmembrane proteins by metalloproteases (MMP) generates numerous essential signaling molecules, but its regulation is not totally understood. CD44, a cleavedExpand
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  • Open Access
Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages
The adhesion molecule and co-receptor of receptor tyrosine kinases, CD44, is expressed in all cells of the immune system, but also in numerous non-immune cells. CD44 plays roles in the cellularExpand
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A global reference dataset for remote sensing of forest biomass. The Forest Observation System approach
Forest biomass is an essential indicator for monitoring the Earth’s ecosystems and climate. It is a critical input to greenhouse gas accounting, estimation of carbon losses and forest degradation,Expand
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Estoque comercial para o segundo ciclo de corte na Floresta Nacional do Tapajós - área experimental KM 67 - Embrapa.
O estudo apresenta o estoque comercial para o segundo ciclo de corte do experimento km 67 da Embrapa Amazonia Oriental. Este volume e de 69,7 m³/ha para o grupo de especies comerciais colhidas emExpand