Anne Preissel

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BACKGROUND The extracellular matrix (ECM) plays an important role in the pathogenesis of atherosclerosis and in-stent restenosis. Elastin is an essential component of the ECM. ECM degradation can lead to plaque destabilization, whereas enhanced synthesis typically leads to vessel wall remodeling resulting in arterial stenosis or in-stent restenosis after(More)
Ischemia/reperfusion (I/R) injury is a main cause of primary dysfunction or non-function after liver transplantation (LTx). Recent evidence indicates that an increase in nitric oxide (NO) production after LTx is associated with I/R injury. The aim of this study was to demonstrate that low-dose FK506 in combination with aminoguanidine (AGH), which leads to a(More)
OBJECTIVE The aim of this study was to demonstrate the feasibility of high-resolution 3-dimensional aortic vessel wall imaging using a novel elastin-specific magnetic resonance contrast agent (ESMA) in a large animal model. MATERIALS AND METHODS The thoracic aortic vessel wall of 6 Landrace pigs was imaged using a novel ESMA and a nonspecific control(More)
Background The extracellular matrix (ECM) plays an important role in the pathogenesis of atherosclerosis and in-stent-restenosis. Elastin is an essential component of the ECM. ECM degradation can lead to plaque destabilization while enhanced synthesis typically leads to vessel wall remodeling resulting in arterial stenosis or in-stent-restenosis following(More)
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