Anne Nanninga

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Several types of copy number variants, or a surplus or absence of genetic information encoded by DNA, appear in the 11.2-13.1 region of chromosome 15. Chromosome 15q11.2-13.1 duplication syndrome (dup15q) is caused by duplications of chromosome 15q11.2-13.1. Angelman syndrome derives from a deletion of the mother’s genetic contribution from the 11.2-13.1(More)
Two synthetic penta deca peptides corresponding to the N-terminal portion (amino acid sequence 1-15) and the C-terminal portion (sequence 32-46) of the pro moiety of the human prorenin (PR) molecule were coupled to BSA and used as antigens to generate antibodies against PR. In a RIA system using the 125I-labeled peptide as tracer, it could be shown that(More)
Prostaglandin F2a (PGF2a) secretion is lowest at midcycle and highest on day 15 at luteolysis in the cycling guinea pig uterus and is inversely related to serum progesterone levels. An increase in 17-b estradiol (E2) occurs only towards the end of the cycle. To investigate the effect of steroids on the control of uterine PGF2ametabolism at the level of gene(More)
Prostaglandin F2 alpha (PGF2 alpha) secretion is lowest at midcycle and highest on day 15 at luteolysis in the cycling guinea pig uterus and is inversely related to serum progesterone levels. An increase in 17-beta estradiol (E2) occurs only towards the end of the cycle. To investigate the effect of steroids on the control of uterine PGF2 alpha metabolism(More)
The title compound 17 has been synthesized for the use as hapten in the development of a competitive enzyme immunoassay for estrogen sulfamates. The synthesis started from estradiol diacetate 2. Oxyfunctionalization at C-11 to give 11alpha-hydroxy steroid 8 was accomplished by hydroboration/alkaline hydrogen peroxide oxidation of the 9(11)-dehydro(More)
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