Anne-Marie Orfila

Learn More
Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae), Caenorhabditis elegans and Drosophila melanogaster. Studies of the effects of genes on ageing are vulnerable to confounding effects of genetic background. Here we re-examined the reported effects of sirtuin(More)
One of the current challenges of neurodegenerative disease research is to determine whether signaling pathways that are essential to cellular homeostasis might contribute to neuronal survival and modulate the pathogenic process in human disease. In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded(More)
The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway may be neuroprotective, the role of Ryk in neurodegenerative disease remains unknown. We found that Ryk is(More)
J. Alex Parker,1,2* Rafael P. Vazquez-Manrique,1,2* Cendrine Tourette,1,2 Francesca Farina,1,2 Nicolas Offner,1,2 Arnab Mukhopadhyay,3 Anne-Marie Orfila,1,2 Aurélie Darbois,1,2 Sophie Menet,1,2 Heidi A. Tissenbaum,3 and Christian Neri1,2,4 1INSERM, Unit 894, Laboratory of Neuronal Cell Biology and Pathology, 75014 Paris, France, 2University Paris Descartes,(More)
  • 1