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Neoplasms of the gallbladder are relatively rare and their preoperative diagnosis that much rarer; leiomyosarcoma of the gallbladder is one of the most infrequent types. The authors had the opportunity to diagnose such a neoplasm preoperatively (although the histological diagnosis was not made). The ultrasound and computed tomographic appearance has not(More)
Twenty-nine patients with necrotizing fasciitis were treated from 1980 to 1988. This study evaluates how the addition of hyperbaric oxygen (HBO) therapy to surgical treatment has affected mortality and the number of debridements required to achieve wound control in these patients. Two groups of patients were viewed: group 1 (n = 12) received surgical(More)
BACKGROUND Circadian rhythmicity of many aspects of cardiovascular function-blood pressure, coagulation and contractile function-is well established, as is diurnal variation in important clinical events, such as myocardial infarction and stroke. Here, we undertake studies to globally assess circadian gene expression in murine aorta. METHODS AND RESULTS(More)
BACKGROUND Hereditary pancreatitis has been shown to be caused by one of two mutations (R117H and N21I) of the cationic trypsinogen gene (PRSS1). Families with hereditary pancreatitis in the north of England were investigated for these mutations. The clinical features associated with each mutation were compared. METHODS In individuals from nine families(More)
Neuroblastoma tumors show a complex interaction of genetic abnormalities, among which some are of significant prognostic importance; however, analysis of chromosome changes in this tumor is often unsuccessful. Twenty primary tumors were studied by comparative genomic hybridization (CGH), and abnormalities were found in 19. While these changes included(More)
Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclein gene could be detected in sixty two sporadic PD and dementia(More)
Os acromiale, failure of fusion of the secondary centers of ossification of the acromion process, has been noted as a contributing factor in shoulder impingement syndrome and rotator cuff tears. Treatments for symptomatic os acromiale with or without rotator cuff tears have been reported in the literature and range from excision of small fragments to fusion(More)
Lung hernia is a protrusion of pulmonary tissue through an abnormal defect in the wall of the thoracic cavity. Though the hernias may be congenital, they are usually acquired following a penetrating injury and surgical intervention. Symptoms are usually vague and infrequent. Pain and discomfort may be present at the site of a chest swelling that increases(More)