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New strategy for the analysis of phenotypic marker antigens in brain tumor-derived neurospheres in mice and humans.
- Anne-Marie Bleau, Brian M. Howard, +5 authors John A. Boockvar
- Biology, Medicine
- Neurosurgical focus
- 1 March 2008
OBJECT Brain tumor stem cells (TSCs) hypothetically drive the malignant phenotype of glioblastoma multiforme (GBM), and evidence suggests that a better understanding of these TSCs will have profound… Expand
Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts
- I. Martín-Padura, Paola Marighetti, +7 authors A. Calvo
- Laboratory Investigation
- 30 April 2012
Hepatocellular carcinoma (HCC) is the fifth most common solid tumor and the third leading cause of cancer-related deaths. Currently available chemotherapeutic options are not curative due in part to… Expand
Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer
BackgroundMortality rates for advanced lung cancer have not declined for decades, even with the implementation of novel chemotherapeutic regimens or the use of tyrosine kinase inhibitors. Cancer Stem… Expand
miR-146a targets c-met and abolishes colorectal cancer liver metastasis.
A major complication of colorectal cancer (CRC), one of the most frequent and deadly types of cancer, is disease progression via liver metastases. At this stage, very few treatment options are… Expand
Metastatic dormancy: a complex network between cancer stem cells and their microenvironment.
- Anne-Marie Bleau, Alice Agliano, Leyre Larzábal, A. L. de Aberasturi, A. Calvo
- Biology, Medicine
- Histology and histopathology
- 2 June 2014
Metastasis represents the major threat of cancer progression and generally emerges years after the detection of the primary tumor. An important rate-limiting step resides in cellular dormancy, where… Expand
The inhibitor of differentiation isoform Id1b, generated by alternative splicing, maintains cell quiescence and confers self-renewal and cancer stem cell-like properties.
Id1 has been shown to play a critical role in tumorigenesis and angiogenesis. Moreover, recent reports have involved Id1 in the maintenance of cancer stem cell features in some tumor types. The Id1… Expand
Co-migration of colon cancer cells and CAFs induced by TGFβ1 enhances liver metastasis
Colorectal cancer (CRC) cells often metastatize to the liver. Cancer-associated fibroblasts (CAFs) enhance metastasis by providing cytokines that create a favorable microenvironment and by inducing… Expand
Safety and Efficacy Clinical Trials for SYL1001, a Novel Short Interfering RNA for the Treatment of Dry Eye Disease.
- J. Benítez-del-Castillo, J. Moreno-Montañés, +11 authors A. Jiménez
- Investigative ophthalmology & visual science
- 1 November 2016
Purpose To evaluate the efficacy and safety of SYL1001, a short interfering (si) RNA targeting the transient receptor potential cation channel subfamily V member 1 (TRPV1), for the treatment of dry… Expand
New syngeneic inflammatory‐related lung cancer metastatic model harboring double KRAS/WWOX alterations
- Anne-Marie Bleau, Javier Freire, +12 authors L. Montuenga
- Biology, Medicine
- International journal of cancer
- 1 December 2014
New mouse models with specific drivers of genetic alterations are needed for preclinical studies. Herein, we created and characterized at the genetic level a new syngeneic model for lung cancer and… Expand
Tivanisiran, a novel siRNA for the treatment of dry eye disease
- J. Moreno-Montañés, Anne-Marie Bleau, A. Jiménez
- Expert opinion on investigational drugs
- 29 March 2018
ABSTRACT Introduction: Dry eye disease (DED) is characterized by an alteration of the tear film with ocular inflammation and neurosensory abnormalities. The main clinical signs of this condition are… Expand