Anne Leselbaum

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BACKGROUND Complex perianal fistulas in Crohn's disease are challenging to treat. Allogeneic, expanded, adipose-derived stem cells (Cx601) are a promising new therapeutic approach. We aimed to assess the safety and efficacy of Cx601 for treatment-refractory complex perianal fistulas in patients with Crohn's disease. METHODS We did this randomised,(More)
OBJECTIVE To investigate the pharmacokinetic profile of a prolonged release, aqueous Autogel formulation of the somatostatin analogue lanreotide (Lan-ATG). DESIGN A phase II, randomized, double-blind study, during which patients received 60, 90 or 120 mg Lan-ATG for four fixed administrations at 28-day intervals. PATIENTS A total of 18 patients with(More)
Large pericardial effusions are now a well-known complication of the acquired immunodeficiency syndrome, mainly caused by mycobacterial disease. However, other etiologies can be found. We report a case of toxoplasma pericarditis without other parasitic localizations. Pericarditis is a very uncommon clinical feature during toxoplasmosis. Its diagnosis is(More)
Objective: To determine the effects of the new somatostatin analogue, lanreotide, in its prolonged released form (PR), in patients with acromegaly. Design: Prospective open multicenter non comparative study. Setting: Thirty-three university-affiliated medical centers. Patients: One hundred sixteen acromegalic patients with active disease, of whom 58(More)
OBJECTIVE To determine the effects of the new somatostatin analogue, lanreotide, in its prolonged released form (PR), in patients with acromegaly. DESIGN Prospective open multicenter non comparative study. SETTING Thirty-three university-affiliated medical centers. PATIENTS One hundred sixteen acromegalic patients with active disease, of whom 58(More)
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