Anne Legler

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Brain aging is associated with cognitive decline that is accompanied by progressive neuroinflammatory changes. The endocannabinoid system (ECS) is involved in the regulation of glial activity and influences the progression of age-related learning and memory deficits. Mice lacking the Cnr1 gene (Cnr1(-/-)), which encodes the cannabinoid receptor 1 (CB1),(More)
Previously we established that some complex compounds of gold with cysteine, glycine, histidine, and tryptophan possess selective antibacterial activity and low toxicity [1, 2]. Recently [3], we reported that the complex compounds of silver with histidine and tryptophan exhibit even higher antibacterial activity with a broad spectrum of action and low(More)
The transcription factors TBX2 and TBX3 are overexpressed in various human cancers. Here, we investigated the effect of overexpressing the orthologous Tbx genes Drosophila optomotor-blind (omb) and human TBX2 in the epithelium of the Drosophila wing imaginal disc and observed two types of cell motility. Omb/TBX2 overexpressing cells could move within the(More)
Previously we established that some complex compounds of gold with glycine, histidine, tryptophan, and cysteine possess selective antibacterial activity and low toxicity [1]. At the same time, virtually no data are available on the properties of complex compounds o f silver with amino acids, including the biological activity of these complexes. In(More)
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