Anne-Laure Iscache

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A new RT-PCR test has been developed to diagnose Chronic bee paralysis virus (CBPV) that is able to detect genetically variable viral isolates. In fact, up to 8.7% divergence between partial nucleotide sequences from viral isolates from French honey bees was highlighted in a preliminary variability study. The previously-described RT-PCR was unable to detect(More)
BACKGROUND Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN)), can interact with pathogens including HIV-1 and is(More)
Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively as conventional mice yield mouse mAbs. Suboptimal efficacy in delivery of human Abs might reflect imperfect interaction between the human membrane IgH chains and the mouse cellular signaling machinery.(More)
The rat is an important biomedical experimental model that benefited from the recent development of new transgenic and knockout techniques. With the goal to optimize rat mAb production and to analyze the impact of Bcl-2 on B-cell development, we generated bcl-2 transgenic rats. Transgenic rats showed Bcl-2 over-expression in B cells, increased B cell(More)
On June 6 2011 was held in Nantes, France, the international meeting ‘‘Transgenesis and genome analysis’’ (http://www.ifr26.nantes.inserm.fr/ITERT/ TRM/). This meeting is the third one of its kind to be organized by the Transgenic Rats Nantes facility (http://www.ifr26.nantes.inserm.fr/ITERT/transgeneserat/). The meeting was supported by academic(More)
On June 8 2009 was held in Nantes, France, the international meeting ‘‘Transgenesis; recent technical developments and applications’’ (see web site for more information ttp://www.ifr26.nantes.inserm.fr/ ITERT/TRM/index.php?num=0). This meeting is the second one of its kind to be organized by the Transgenic Rats Nantes facility (http://www.ifr26.(More)
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