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Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation
Summary Although cellular tumor-suppression mechanisms are widely studied, little is known about mechanisms that act at the level of tissues to suppress the occurrence of aberrant cells in epithelia.Expand
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JAK/STAT signalling mediates cell survival in response to tissue stress
Tissue homeostasis relies on the ability of tissues to respond to stress. Tissue regeneration and tumour models in Drosophila have shown that c-Jun amino-terminal kinase (JNK) acts as a prominentExpand
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Calcium spikes, waves and oscillations in a large, patterned epithelial tissue
While calcium signaling in excitable cells, such as muscle or neurons, is extensively characterized, calcium signaling in epithelial tissues is little understood. Specifically, the range ofExpand
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JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress
The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processesExpand
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Response of Drosophila epithelial cell and tissue shape to external forces in vivo
ABSTRACT How actomyosin generates forces at epithelial adherens junctions has been extensively studied. However, less is known about how a balance between internal and external forces establishesExpand
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A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity
In addition to apicobasal polarization, some epithelia also display polarity within the plane of the epithelium. To what extent polarized endocytosis plays a role in the establishment and maintenanceExpand
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DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis
BackgroundTracking dynamic protein–chromatin interactions in vivo is key to unravel transcriptional and epigenetic transitions in development and disease. However, limited availability andExpand
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Regulation of tensile stress in response to external forces coordinates epithelial cell shape transitions with organ growth and elongation
The role of actomyosin contractility at epithelial adherens junctions has been extensively studied. However, little is known about how external forces are integrated to establish epithelial cell andExpand
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Correction to: DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis
Unfortunately, the original version of this article contained a typographical error in one of the author names. The name of the author Alexey Pindyurin was incorrectly spelt as Alexey Pinduyrin. TheExpand