Learn More
Mammalian cell nuclei exhibit discrete sites where specific proteins characteristically localize. PML nuclear bodies (PML NBs) (nuclear domain 10s (ND10s)) are the primary localization site for the promyelocytic leukemia (PML) protein and the SP100 autoantigen. The observations that some PML and SP100 isoforms can function as transcriptional regulators,(More)
SP100A and SP100B are mammalian nuclear proteins encoded by alternatively-spliced transcripts from the SP100 gene. The N-terminal portion of SP100B (aa 1-476) is identical to SP100A and contains an HP1 interaction domain. The C-terminal portion of SP100B (aa 477-688) contains an HMG2 interaction domain and a SAND domain. The SAND domain is a DNA-binding(More)
  • 1