Anne Hanselmann

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This study tests the hypothesis that reperfusion injury is the principal cause of limb loss after acute arterial occlusion and that this injury is avoidable. Of 61 isolated hindlimbs amputated at the level of the hip joint, 17 were controls (group I), 5 were perfused without ischemia to establish the validity of the model (group II), and 15 underwent 4(More)
Four hours of complete normothermic ischemia in the rat hindlimb has been thought to produce extensive and irreversible damage and no possibility of salvage by reperfusion. This study tests the hypothesis that, in contrast to conventional wisdom, the cellular integrity is preserved after 4 hours of complete warm ischemia and control of the initial(More)
Undirected cycles in Bayesian networks are often treated by using clustering methods. This results in networks with nodes characterized by joint probability densities instead of marginal densities. An efficient representation of these hybrid joint densities is essential especially in nonlinear hybrid net works containing continuous as well as discrete(More)
In this paper, we present a novel approach to parametric density estimation from given samples. The samples are treated as a parametric density function by means of a Dirac mixture, which allows for applying analytic optimization techniques. The method is based on minimizing a distance measure between the integral of the approximation function and the(More)
Previous studies from the authors' laboratory have shown that controlled limb perfusion after prolonged, acute ischaemia minimizes reperfusion injury. The present study was performed to investigate the role of osmotic and colloid-osmotic pressure in the initial reperfusate in order to reduce postischaemic limb oedema and subsequent reperfusion injury. A(More)
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