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The rate of loss of albumin to the tissue spaces (measured as transcapillary escape rate) rose by more than 300% in patients with septic shock, and the average increase within 7 h of cardiac surgery was 100%. The transcapillary escape rate in cachectic cancer patients was twice that of a group of healthy individuals. The rate of loss of albumin to the(More)
The rate at which the acute phase protein response occurred after both major and minor surgery was explored. Increases in the plasma concentration of C-reactive protein (CRP), alpha-1-acid glycoprotein (alpha 1 AG) and fibrinogen were not detected until 6-8 h after the initial incision. The peak concentration of CRP occurred at 48 h and that of fibrinogen(More)
  • Anne Fleck
  • The Proceedings of the Nutrition Society
  • 1989
1. When assessing the significance of altered plasma protein concentrations the various physiological factors, including posture and hormones which affect the amount and distribution of fluid in the body and the synthesis and catabolism of plasma proteins, must be kept in mind. 2. Although several cytokines, including IL-1 and TNF, are implicated in the(More)
The early time course of the acute phase protein response (APPR) and mediators involved in its control were investigated in the rat and mouse. After turpentine-induced inflammation in the rat C-reactive protein and fibrinogen increased in concentration peaking at 48 h and 18-24 h, respectively. A 9 h delay prior to elevation of these protein was observed.(More)