Anne Elisabeth Heng

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BACKGROUND Information about chronic dialysis (CD) patients admitted to intensive care units (ICU) is scant. This study sought to determine the epidemiology and outcome of CD patients in an ICU setting and to test the performance of the Simplified Acute Physiology Score (SAPS II) to predict hospital mortality in this population. METHODS All consecutive CD(More)
BACKGROUND Little is known about vascular access infections in patients with acute renal failure. METHODS We prospectively compared infection rates of dialysis catheters (DCs) and central venous catheters (CVCs) in patients in the intensive care unit treated with renal replacement therapy for acute renal failure. The same insertion and maintenance(More)
Catheter colonization is commonly used as an end point in studies on central venous catheter (CVC) infections. This study aimed at comparing the rates of catheter colonization in patients according to the administration of antibiotics at removal. Prospective study over a 5-year period. All patients with a CVC removed without suspicion of CVC infection were(More)
BACKGROUND There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kidney injury (AKI). METHODS We performed a retrospective single-center cohort study of patients treated with IHD for at least 7 days and(More)
PURPOSE Post-transplantation lymphoproliferative disorder (PTLD) is associated with significant mortality in kidney transplant recipients. We conducted a prospective survey of the occurrence of PTLD in a French nationwide population of adult kidney recipients over 10 years. PATIENTS AND METHODS A French registry was established to cover a nationwide(More)
A 65-year-old male with advanced colorectal cancer treated by sigmoidectomy and FOLFOX 6 regimen was admitted to the ICU after five cycles because of anuric acute renal failure (ARF) and thrombocytopenia (Table 1). Chemotherapy consisted in a combination of OXP, 5-fluorouracil (5-FU) and folinic acid. He had received a total dosage of 470 mg of OXP when(More)
Anti-tumor necrosis factor-α (TNFα) therapy has improved the prognosis of many chronic inflammatory diseases. It appears to be well-tolerated by liver-transplant patients. However, their use and their safety in kidney-transplant patients have yet to be determined.In this retrospective study, we identified 16 adult kidney-transplant patients aged 46.5 years(More)
INTRODUCTION Therapeutic drug monitoring of mycophenolate mofetil is recommended because of the interindividual variability in the exposition to its active moiety, mycophenolic acid. However, most of the pharmacokinetic studies involved patients cotreated with cyclosporine (INN, ciclosporin). METHODS We analyzed the pharmacokinetics of mycophenolic acid(More)
BACKGROUND Rituximab has shown encouraging results for the treatment of kidney transplantation recipients with focal segmental glomerulosclerosis (FSGS) recurrence. However, the correct, opportune, and safe use of rituximab for this indication remains to be determined. METHODS This multicenter retrospective study reports on 19 new cases aged 35 (15-66)(More)