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The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
The preservation of germ cell sexual identity is essential for gametogenesis. Here we show that H3K9me3-mediated gene silencing is integral to female fate maintenance in Drosophila germ cells. GermExpand
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Maintenance of Drosophila germline stem cell sexual identity in oogenesis and tumorigenesis
Adult stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. In Drosophila females, germline stem cells (GSCs) require Sex lethal (Sxl) to exit the stem cell state andExpand
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An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline
Maintenance of germ cell sexual identity is essential for reproduction. Entry into the spermatogenesis or oogenesis pathway requires that the appropriate gene network is activated and the antagonistExpand
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The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells by repressing expression of key spermatogenesis genes
The preservation of germ cell sexual identity is essential for gametogenesis. Here we show that H3K9me3-mediated gene silencing is integral to female fate maintenance in Drosophila germ cells. GermExpand
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An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline
ABSTRACT Maintenance of germ cell sexual identity is essential for reproduction. Entry into the spermatogenesis or oogenesis pathway requires that the appropriate gene network is activated and theExpand
H3K9 methylation maintains female identity in Drosophila germ cells through repression of the spermatogenesis program
Maintaining germ cell sexual identity is critical for gametogenesis. We find that Drosophila female germ cells employ H3K9me3 marked euchromatin, operationally defined as facultative heterochromatin,Expand
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