Anne E. Goldfeld

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Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis.

F P Blanc, Thim Sok, +20 authors Anne E. Goldfeld
The New England journal of medicine
2011

BACKGROUND Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiation… (More)

IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage.

Anne O'Garra, Pedro Lima Vieira, Paulo Vieira, Anne E. Goldfeld
The Journal of clinical investigation
2004

Effective immune responses against pathogens are sometimes accompanied by strong inflammatory reactions. To minimize damage to self, the activation of the immune system also triggers… (More)

A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo.

Eunice Y. Tsai, James V. Falvo, +7 authors Anne E. Goldfeld
Molecular and cellular biology
2000

The tumor necrosis factor alpha (TNF-alpha) gene is rapidly activated by lipopolysaccharide (LPS). Here, we show that extracellular signal-regulated kinase (ERK) kinase activity but not calcineurin… (More)

Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity.

Pedro O Flores-Villanueva, Edmond J. Yunis, +11 authors Anne E. Goldfeld
Proceedings of the National Academy of Sciences…
2001

Certain HLA-B antigens have been associated with lack of progression to AIDS. HLA-B alleles can be divided into two mutually exclusive groups based on the expression of the molecular epitopes HLA-Bw4… (More)

IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.

Vassiliki A Boussiotis, Eunice Y. Tsai, +7 authors Anne E. Goldfeld
The Journal of clinical investigation
2000

The lethality of Mycobacterium tuberculosis remains the highest among infectious organisms and is linked to inadequate immune response of the host. Containment and cure of tuberculosis requires an… (More)

Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide.

Anne E. Goldfeld, Carolyn Doyle, Tom Maniatis
Proceedings of the National Academy of Sciences…
1990

We have identified a region of the human tumor necrosis factor alpha (TNF-alpha) gene promoter that is necessary for maximal constitutive, virus-induced, and lipopolysaccharide (LPS)-induced… (More)

Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp.

Eunice Y. Tsai, Jugnu Jain, Patricia A Pesavento, Anjana Rao, Anne E. Goldfeld
Molecular and cellular biology
1996

The human tumor necrosis factor alpha (TNF-alpha) gene is one of the earliest genes expressed upon the activation of a T or B cell through its antigen receptor. Previous experiments have demonstrated… (More)

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production

Daisuke Hata, Yuko Kawakami, +14 authors Toshiaki Kawakami
The Journal of experimental medicine
1998

We investigated the role of Bruton's tyrosine kinase (Btk) in FcepsilonRI-dependent activation of mouse mast cells, using xid and btk null mutant mice. Unlike B cell development, mast cell… (More)

Ethnic-specific genetic associations with pulmonary tuberculosis.

Julio C Delgado, Andres Baena, Sok Thim, Anne E. Goldfeld
The Journal of infectious diseases
2002

Several susceptibility-associated genetic polymorphisms have been proposed to explain differential susceptibility to tuberculosis (TB) disease progression in different populations. Here,… (More)

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter

Anne E. Goldfeld, Patricia G. McCaffrey, Jack Leonard Strominger, Anjana Rao
The Journal of experimental medicine
1993

Tumor necrosis factor alpha (TNF-alpha), a cytokine with pleiotropic biological effects, is produced by a variety of cell types in response to induction by diverse stimuli. In this paper, TNF-alpha… (More)

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