Learn More
residues in the Ϫ1 to ϩ2 positions for recognition of the substrate arginine (for a detailed compilation of methyl-arginine contexts, see Gary and Clarke, 1998). sparked by the identification of multiple arginine methyl-Dana-Farber Cancer Institute transferase encoding genes. Although these genes have Boston, Massachusetts 02115 been uncovered in a variety(More)
Background: In response to policy recommendations, nine National Institute for Health Research (NIHR) Collaborations for Leadership in Applied Health Research and Care (CLAHRCs) were established in England in 2008, aiming to create closer working between the health service and higher education and narrow the gap between research and its implementation in(More)
The protein Sam68 (Src-associated in mitosis, 68 kDa) has been found to bind to SH2 and to SH3 domain-containing proteins and to RNA. Although its protein-protein interactions implicate Sam68 in cell signaling, the significance of its RNA binding remains obscure. In most cells, Sam68 shows diffuse nucleoplasmic staining. Upon treatment with transcription(More)
The discovery of roles for arginine methylation in intracellular transport and mRNA splicing has focused attention on the methylated arginine-glycine (RG)-rich domains found in many eukaryotic RNA-binding proteins. Sequence similarity among these highly repetitive RG domains, combined with interactions between RG-rich proteins, raises the question of(More)
INTRODUCTION Nursing staffing levels in hospitals appear to be associated with improved patient outcomes. National guidance indicates that the triangulation of information from workforce planning and deployment technologies (WPTs; eg, the Safer Nursing Care Tool) and 'local knowledge' is important for managers to achieve appropriate staffing levels for(More)
The effective rehabilitation of detained youth begins with optimal screening of their mental health needs as they enter the juvenile delinquency system. The Massachusetts Youth Screening Instrument-Version 2 is the most used and empirically proven tool to screen juveniles. Juvenile facilities should consider the use of screening instruments like the(More)
BACKGROUND On average, people with schizophrenia and psychosis die 13-30 years sooner than the general population (World Psychiatry 10 (1):52-77, 2011). Mental and physical health care is often provided by different organisations, different practitioners and in different settings which makes collaborative care difficult. Research is needed to understand and(More)
  • 1