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BACKGROUND In patients with aortic stenosis, pressure overload induces cardiac hypertrophy and fibrosis. Female sex and estrogens influence cardiac remodeling and fibrosis in animal models and in men. Sex differences and their molecular mechanisms in hypertrophy regression after aortic valve replacement have not yet been studied. METHODS AND RESULTS We(More)
OBJECTIVE To examine whether the predictive value of gender for health-related quality of life (HRQoL) is independent of clinical health status and depression. Women undergoing coronary bypass surgery generally report a poorer HRQoL than men. METHODS A total of 990 (20% women) patients completed study questionnaires 1 day before coronary bypass surgery(More)
Sodium is an essential mineral for all vertebrates regulating electrolyte-homeostasis. The sense of taste promotes the intake of salt in order to compensate for the permanent loss of sodium through excretion. In rodents, salt taste is thought to involve several transduction pathways. One is elicited by various cations and cetylpyridinium-chloride-sensitive,(More)
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