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Serotonin (5-HT) has been shown to affect the development and patterning of the mouse barrelfield. We show that the dense transient 5-HT innervation of the somatosensory, visual, and auditory cortices originates in the thalamus rather than in the raphe: 5-HT is detected in thalamocortical fibers and most 5-HT cortical labeling disappears after thalamic(More)
Villin is an actin-binding protein localized in intestinal and kidney brush borders. In vitro, villin has been demonstrated to bundle and sever F-actin in a Ca(2+)-dependent manner. We generated knockout mice to study the role of villin in vivo. In villin-null mice, no noticeable changes were observed in the ultrastructure of the microvilli or in the(More)
Villin is an actin-binding protein localized in intestinal and kidney brush borders. In vitro, villin has been demonstrated to bundle and sever F-actin in a Ca 2 ϩ-dependent manner. We generated knockout mice to study the role of villin in vivo. In villin-null mice, no noticeable changes were observed in the ultrastructure of the microvilli or in the(More)
An analysis of sperm abnormalities can be used as a rapid method to determine the mutagenic potential of chemical agents as well as the toxic potential of chemicals on the whole animal. O-Xylene was investigated for its potential mutagenicity by the sperm abnormality assay. Sprague Dawley rats 10-16 weeks old were injected intraperitoneally (ip) with 0.5(More)
Pulmonary alveolar macrophages (PAM) from rats exposed to a single dose of ZnO or NiO showed distinct changes in size and ultrastructure. ZnO exposure brought about considerable reduction in the size of the cells, which can be distinguished into two types of macrophages. The macrophages contained a prominent nucleolus, several primary and secondary(More)
The morphological effects of single intratracheal injections of copper oxide (CuO) and cadmium oxide (CdO) (5 mg) on rat alveolar macrophages were studied. Rats sacrificed after a one week recovery period showed distinct morphological changes induced by CuO and CdO. Copper oxide induced hypertrophy of both the alveolar macrophages as well as the epithelial(More)
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