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OBJECTIVE The purposes of this study were to investigate whether reduced lung function is associated with metabolic syndrome (MS) and diabetes (DM) in American Indians (AIs) and to determine whether lower pulmonary function presents before the development of DM or MS. RESEARCH DESIGN AND METHODS The Strong Heart Study (SHS) is a multicenter, prospective(More)
The ability of an animal to cope with new environments arises from its capacity to respond to environmental variables and maintain body equilibrium (homeostasis). Each compensating mechanism depends on, and is a part of, a physiological feedback process. The severity (intensity and duration) of an environmental change relative to the animal's capacity to(More)
BACKGROUND The endoplasmic reticulum (ER) stress response participates in many chronic inflammatory and autoimmune diseases. In the current study, we sought to examine the contribution of ER stress transducers in the pathogenesis of three principal facets of allergic asthma: inflammation, airway fibrosis, and airways hyperresponsiveness. METHODS House(More)
BACKGROUND Obese asthmatics tend to have poorly controlled asthma, and resistance to standard asthma controller medications. The purpose of this study was to determine the efficacy of pioglitazone, an anti-diabetic medication which can alter circulating adipokines and have direct effects on asthmatic inflammation, in the treatment of asthma in obesity. (More)
BACKGROUND Sinusitis and rhinitis are associated with uncontrolled asthma. There are no simple, validated tools to screen for these diseases. The objective of this study was to assess instruments to assist in the diagnosis of chronic sinonasal disease. METHODS Participants without acute sinonasal symptoms underwent an extensive evaluation. The results(More)
AIRWAY HYPERRESPONSIVENESS is a defining characteristic of asthma, and airway smooth muscle function is a critical determinant of this airway responsiveness (7). Current therapies that target airway smooth muscle function in asthma, short-and long-acting bronchodilators, induce relaxation of smooth muscle ; their major mode of action targets a symptom, not(More)
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