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To determine the effects on hemodynamics, laboratory parameters, and renal function of terlipressin used in septic-shock patients with hypotension not responsive to high-dose norepinephrine (>2.0 microg x kg(-1) x min(-1)) and dopamine (25 microg x kg(-1) x min(-1)), a prospective, open-label study was carried out in 17 patients. Patients received one or(More)
OBJECTIVE To compare, in patients with hyperdynamic septic shock, the effects of norepinephrine or terlipressin on hemodynamic variables and renal function. DESIGN Prospective, randomized, open-label study. SETTING Intensive care unit of a university, tertiary, and referral center. PATIENTS Twenty adult patients with hyperdynamic septic shock, after(More)
Vasopressin (antidiuretic hormone) is emerging as a potentially major advance in the treatment of septic shock. Terlipressin (tricyl-lysine-vasopressin) is the synthetic, long-acting analogue of vasopressin, and has comparable pharmacodynamic but different pharmacokinetic properties. Vasopressin mediates vasoconstriction via V1 receptor activation on(More)
OBJECTIVE To measure the effects of increasing mean arterial pressure on oxygen variables and renal function in septic shock. DESIGN Prospective, open-label, randomized, controlled study. SETTING Medical-surgical intensive care unit of a tertiary care teaching hospital. PATIENTS Twenty-eight patients with a diagnosis of septic shock who required fluid(More)
BACKGROUND The target blood concentrations of propofol and remifentanil, when used in combination, required to blunt the cough response to tracheal intubation, cuff inflation, and tracheal suctioning without neuromuscular blocking agents are not known. METHODS In a randomized prospective study, 81 patients were enrolled to determine which of three target(More)
INTRODUCTION The aim of our study was to understand the motivations of outpatients who come to dermatological emergencies in a university hospital. PATIENTS AND METHOD This 6-week prospective study included outpatients who came to the dermatology emergency unit. This consultation is proposed each morning (from 8 to 9), from Mondays to Fridays. A(More)