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BAliBASE is specifically designed to serve as an evaluation resource to address all the problems encountered when aligning complete sequences. The database contains high quality, manually constructed multiple sequence alignments together with detailed annotations. The alignments are all based on three-dimensional structural superpositions, with the(More)
Four cases of chondrosarcoma of the skull are presented. The clinical and radiographic features and differential diagnosis are discussed. The previous literature is reviewed and all cases tabulated. Computed tomography and angiography are important radiologic tools in suggesting the correct diagnosis prior to operation. Stippled, finely speckled, or(More)
In a prospective, multicenter study of 164 patients, cerebral magnetic resonance (MR) angiography with multiple overlapping thin slab acquisition was evaluated for image quality and diagnostic accuracy. Of the 164 patients, 87 (53%) underwent either correlative cut-film angiography or surgery. The overall image quality was excellent in 90% of patient(More)
A prospective evaluation for occult pneumothorax was performed in 25 consecutive patients with serious head trauma by combining a limited chest CT examination with the emergency head CT examination. Of 21 pneumothoraces present in 15 patients, 11 (52%) were found only by chest CT and were not identified clinically or by supine chest radiograph. Because of(More)
In vivo experiments in dogs demonstrated angiographically that the subarachnoid injection of blood produced cerebral arterial apasm both immediately after the injection of blood and 2 days later. The sublingual adminstration of nifedipine reversed both the acute and the delayed cerebral arterial spasm. In addition, sublingual administration of nifedipine 20(More)
OBJECTIVE Multiple overlapping thin-slab acquisition (MOTSA) is a hybrid time-of-flight MR angiography technique that combines the advantages of two- and three-dimensional methods. A venetian blind-like artifact, resulting from variations in signal intensity at slab boundaries, is a potentially significant disadvantage. The objective of this study was to(More)
We describe a light-guidance system that uses intersecting helium-neon laser beams to provide precise guidance for biopsy approaches from any direction (including compound angles) during CT-guided biopsy of the chest and abdomen. Interactive software provides visualization of the proposed path, indicates the segment of that path that will pass through each(More)
Six cases of sarcoidosis involving the central nervous system are reported with the neuroradiological findings and appearance on computed tomography. Communicating hydrocephalus with sarcoid arachnoiditis is the most common finding, but arteritis and masses have also been reported. Two rare cases of intracerebral masses are included. The radiological(More)
BACKGROUND A well-characterized dog model of the X-linked collagen disease Alport syndrome (XLAS) was used to study the effect of progressive glomerular disease on megalin-mediated endocytosis. In XLAS, altered structure and function of the glomerular basement membrane induces a progressive proteinuric nephropathy. METHODS The investigation was performed(More)
Detailed analysis of all neurologic and neurosurgical admissions at Johns Hopkins Hospital for 6 months prior to the second 6 months after installation of a CT head scanner was undertaken in an attempt to identify the effect CT had on health care decisions, costs, and morbidity. Data showed decreased cost of more than $2,000 per patient and shorter length(More)