Annamaria Nosari

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BACKGROUND AND OBJECTIVES The aim of this study was to evaluate the incidence and outcome of invasive fungal infections (IFI) in patients with hematologic malignancies. DESIGN AND METHODS This was a retrospective cohort study of patients admitted between 1999 and 2003 to 18 hematology wards in Italy. Each participating center provided information on all(More)
BACKGROUND The prophylactic use of fluoroquinolones in patients with cancer and neutropenia is controversial and is not a recommended intervention. METHODS We randomly assigned 760 consecutive adult patients with cancer in whom chemotherapy-induced neutropenia (<1000 neutrophils per cubic millimeter) was expected to occur for more than seven days to(More)
BACKGROUND The aim of this study was to evaluate prognostic factors, treatments and outcome of invasive aspergillosis in patients with acute myeloid leukemia based on data collected in a registry. DESIGN AND METHODS The registry, which was activated in 2004 and closed in 2007, collected data on patients with acute myeloid leukemia, admitted to 21(More)
BACKGROUND AND OBJECTIVES To evaluate the clinical characteristics of patients affected by hematologic malignancies who developed mucormycosis and to ascertain the factors which influenced the outcome following mycotic infection. DESIGN AND METHODS This was a retrospective study conducted over a 15-year period (1987-2001). The study included 59 patients(More)
L. Pagano, M. Caira, A. Nosari, M. T. Van Lint, A. Candoni, M. Offidani, T. Aloisi, G. Irrera, A. Bonini, M. Picardi, C. Caramatti, R. Invernizzi, D. Mattei, L. Melillo, C. de Waure, G. Reddiconto, L. Fianchi, C. G. Valentini, C. Girmenia, G. Leone, and F. Aversa Istituto di Ematologia and Unità di Epidemiologia e Biostatistica, Istituto di Igiene,(More)
BACKGROUND The purpose of our study was to evaluate the incidence and outcome of invasive fungal infection (IFI) among patients who underwent autologous or allogeneic hematopoietic stem cell transplantation (HSCT) at 11 Italian transplantation centers. METHODS This cohort-retrospective study, conducted during 1999-2003, involved HSCT patients admitted to(More)
OBJECTIVE To compare the efficacy and tolerability of fluconazole and oral amphotericin B in preventing fungal infection in neutropenic patients with acute leukemia. DESIGN A randomized, controlled, multicenter trial. SETTING 30 hematologic units in tertiary care or university hospitals. PATIENTS 820 consecutive, afebrile, adult patients with acute(More)
A retrospective study of 37 patients with haematological malignancy (21 acute myeloid leukaemia, 11 acute lymphoid leukaemia, two lymphoma, two hairy cell leukaemia, one Hodgkin's disease) and histologically documented mucormycosis was conducted to evaluate the clinical characteristics and ascertain the factors which influenced the outcome from mycotic(More)