Annamaria Carusi

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Computational models in physiology often integrate functional and structural information from a large range of spatiotemporal scales from the ionic to the whole organ level. Their sophistication raises both expectations and skepticism concerning how computational methods can improve our understanding of living organisms and also how they can reduce,(More)
Biological knowledge is increasingly represented as a collection of (entity-relationship-entity) triplets. These are queried, mined, appended to papers, and published. However, this representation ignores the argumentation contained within a paper and the relationships between hypotheses, claims and evidence put forth in the article. In this paper, we(More)
Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis,(More)
BACKGROUND A reduction of heart rate (HR) by surgical means or pharmacological agents affects the progression and/or regression of atherosclerotic lesions. Nevertheless, the effect of bradycardia per se on large artery structure and function has never been investigated in rat models of hypertension. METHODS Four groups of Wistar-Kyoto (WKY) rats and(More)
Physiological variability manifests itself via differences in physiological function between individuals of the same species, and has crucial implications in disease progression and treatment. Despite its importance, physiological variability has traditionally been ignored in experimental and computational investigations due to averaging over samples from(More)
In recent years there has been growing attention to the epistemology of clinical decision-making, but most studies have taken the individual physicians as the central object of analysis. In this paper we argue that knowing in current medical practice has an inherently social character and that imaging plays a mediating role in these practices. We have(More)
To Kassandra Pomper, for her support and companionship during all the stages of this book —Juan To Rolf Ital who spoiled me by buying me my first computer for my twelfth birthday —Eckhart INTRODUCTION William Aspray recorded the first use of computers for scientific usage between 1952 and 1957. By June of 1952, the IAS computer was finished and ready to be(More)
Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterisation of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis,(More)
In the last few years it has been pointed out that, from both physical and dynamical point of view, it is becoming more and more difficult to distinguish comets from asteroids and indeed there are some examples of small bodies first designated as comets which had, later, to be reclassified as asteroids and vice versa (Hartmann et al., 1990; McFadden, 1994).(More)
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