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The specific binding of nuclear protein(s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C.

• Annalisa Verri, Paolo Mazzarello, Giuseppe Biamonti, Silvio Spadari, Federico Focher
• Nucleic acids research
• 1990

Point mutations in the cAMP-responsive element (CRE) of the rat somatostatin gene promoter/enhancer sequence (TGACGTCA) were used as a model for assessing the effect of uracil, deriving either from… (More)

Uracil in Oris of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?

• Federico Focher, Annalisa Verri, Simona Verzeletti, Paolo Mazzarello, Silvio Spadari
• Chromosoma
• 1992

We have recently demonstrated that mammalian uracil-DNA glycosylase activity is undetectable in adult neurons. On the basis of this finding we hypothesized that uracil, derived either from oxidative… (More)

DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.

• Annalisa Verri, Simona Verzeletti, +6 authors Federico Focher
• Anticancer research
• 1992

The activity of nuclear DNA polymerases alpha, beta and delta/epsilon, uracil-DNA glycosylase, thymidine kinase and the presence of Proliferating Cell Nuclear Antigen (PCNA) have been examined in… (More)

Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives.

• Federico Focher, Annalisa Verri, Silvio Spadari, Roberto Manservigi, J J Gambino, G. E. Wright
• The Biochemical journal
• 1993

We have purified Herpes simplex type 1 (HSV1) uracil-DNA glycosylase from the nuclei of HSV1-infected HeLa cells harvested 8 h post-infection, at which time the induction of the enzyme is a maximum.… (More)

Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon.

• G. E. Wright, Ulrich Hübscher, Naseema N. Khan, Federico Focher, Annalisa Verri
• FEBS letters
• 1994

Quantitative effects of inhibitors of the replicative DNA polymerases (pol) alpha, delta and epsilon from calf thymus are reported under similar assay conditions. Carbonyldiphosphonate was a… (More)

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.

• Andrzej Manikowski, Annalisa Verri, +5 authors G. E. Wright
• Journal of medicinal chemistry
• 2005

Derivatives of the herpes simplex thymidine kinase inhibitor HBPG [2-phenylamino-9-(4-hydroxybutyl)-6-oxopurine] have been synthesized and tested for inhibitory activity against recombinant enzymes… (More)

Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development.

• Federico Focher, Paolo Mazzarello, Annalisa Verri, Ulrich Hübscher, Silvio Spadari
• Mutation research
• 1990

We have shown that DNA polymerase beta, the only nuclear DNA polymerase present in adult neurons, cannot discriminate between dTTP and dUTP, having the same Km for both substrates. This fact suggests… (More)

Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.

• Silvio Spadari, Giovanni Maga, Annalisa Verri, Federico Focher
• Expert opinion on investigational drugs
• 1998

As a general rule, enzymes act on only one enantiomer of a chiral substrate and only one of the enantiomeric forms of a chiral molecule may bind effectively at the catalytic site, displaying… (More)

L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?

• Annalisa Verri, Alessandra Montecucco, +4 authors Federico Focher
• The Biochemical journal
• 1999

We demonstrate that l-ATP is recognized by some enzymes that are involved in the synthesis of nucleotides and nucleic acids. l-ATP, as well as its natural d-enantiomer, acts as a phosphate donor in… (More)

Herpes simplex virus type 1 (HSV-1) uracil-DNA glycosylase: functional expression in Escherichia coli, biochemical characterization, and selective inhibition by 6-(p-n-octylanilino)uracil.

• Rafaela Argnani, Federico Focher, +4 authors Roberto Manservigi
• Virology
• 1995

The Herpes simplex virus type 1 (HSV-1) uracil-DNA glycosylase (UDG) is encoded by the UL2 gene. The translation from the first putative start codon of UL2 predicts a polypeptide of 334 residues,… (More)

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