Annalee Reid

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The effects of betamethasone on the elevation of rat plasma corticosterone levels by nicotine (400 microgram/kg s.c.), urethane anaesthesia and psychological stress have been studied. Betamethasone pretreatment (5 mg/kg given in the drinking water over 24 hr) initially suppressed the response to all three stimuli but, after 24 hr, only the response to(More)
The effect of baclofen and clonidine, both individually and in combination, on noradrenaline turnover was examined in several brain regions as well as in the spinal cord using the α-methyl-p-tyrosine depletion method. Baclofen (30–50 mg/kg) consistently increased the turnover of noradrenaline in the cortex, hippocampus and spinal cord and this effect was(More)
The hemodynamic responses to bolus injection of endothelin I (ET) at 5, 15, and 50 micrograms were examined in conscious sheep (n = 5) before and after infusion of nisoldipine at 25 micrograms/kg/h. Endothelin produced dose-dependent increases in mean arterial pressure (MAP + 87 +/- 6 mm Hg at 50 micrograms) and calculated total peripheral resistance (CTPR(More)
1. Synthetic human endothelin-1 was infused intravenously at 15 micrograms/h for 24 h to examine its cardiovascular actions in five conscious sheep. 2. Endothelin produced a maximum increase in mean arterial pressure (MAP) of +8 mmHg at 8 h, with an increase in calculated total peripheral resistance (CTPR) of +2.6 mmHg/L per min, whilst cardiac output (CO)(More)
The pharmacology of Avena sativa has been investigated in laboratory animals following a report that tincture of Avena sativa reduced the craying for cigarettes in man. The tincture, evaporated to dryness, craving for cigarettes in man. The tincture, evaporated to dryness, re-constituted in an equal volume of water and administered by stomach tube or(More)