Anna Zagryazhskaya

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Lung cancer is recognized as a leading cause of cancer-related deaths worldwide. Over the past several years, evidence emerged that microRNAs (miRNAs), a class of small non-coding RNA molecules regulating gene expression at posttranscriptional level, play an important role in cell functioning, as well as in human diseases. Here, we analyzed expression of(More)
Lung cancer is a leading cause of cancer deaths worldwide. Development of lung cancer is associated with exposure to carcinogens such as tobacco smoke and some environmental factors. The incidence of lung cancer increases with age, particularly after age 60. It was estimated that less than 2% of all lung cancer cases occurred in patients younger than 45;(More)
Present: Due to a technical error during image processing, an incorrect high resolution version of Figure 7 was included with the manuscript. A549 cells treated as indicated (Scale bar, 10 μm); B. Cleavage of PARP and γH2AX level in A549 cells treated as indicated. GAPDH was used as loading control. C. TUNEL staining of DNA strand breaks (top image) and(More)
Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC), the major lung cancer subtype, is characterized by high resistance to chemotherapy. Here we demonstrate that Tudor staphylococcal nuclease (SND1 or TSN) is overexpressed in NSCLC cell lines and tissues, and is important for maintaining NSCLC(More)
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