Anna Szuro-Sudol

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Each of 11 tumors tested produced a factor that markedly suppressed the ability of macrophages to release H2O2 or O.2- in response to phorbol myristate acetate or zymosan. Four of seven normal cell types produced a similar activity, which was 3.5-7 times lower in titer than that in tumor cell-conditioned medium (TCM), and which was much more rapidly(More)
To determine whether extracellular tryptophan degradation represents an oxygen-independent antimicrobial mechanism, we examined the effect of exogenous tryptophan on the intracellular antimicrobial activity of gamma interferon (IFN-gamma)-stimulated human macrophages. IFN-gamma readily induced normal monocyte-derived macrophages (MDM) to express indoleamine(More)
Macrophages from tumor-bearing hosts or macrophages incubated with tumor cells, tumor lysates, or tumor cell-conditioned medium (TCM) 1 are often defective in their maturation (1, 2), chemotaxis in vitro or accumulation in vivo (3-14), spreading (15, 16), phagocytosis (17-19), or antimicrobial activity (20) (reviewed in 21). However, few effects of tumor(More)
Medium conditioned by tumor cells (TCM) and certain nonmalignant cells contains a trypsin-sensitive factor that suppresses macrophage oxidative metabolism. Because the killing of intracellular pathogens such as Toxoplasma gondii and Leishmania donovani by macrophages is largely oxygen-dependent, we tested the effect of TCM on the antiprotozoal activity of(More)
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