Anna Szczepańska-Szerej

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OBJECTIVE This open-label, phase 3b study evaluated the effectiveness and tolerability of tapentadol prolonged release and tapentadol immediate release (for acute pain episodes) for severe, chronic low back pain with or without a neuropathic pain component that was inadequately managed in patients taking World Health Organization (WHO) Step I or II(More)
MMP-9 plays an important role in the pathogenesis of AIS and predicts haemorrhagic transformation of the ischaemic focus. The aim of our study was to analyse both serum MMP-9 and its most specific endogenous inhibitor (TIMP-1) levels in AIS and to check whether HMG-CoA reductase inhibitor (simvastatin) affects the MMP-9/TIMP-1 ratio value. Fifty patients(More)
Like other proinflammatory cytokines, TNF-alpha may play an important role in the development of central nervous system injury following ischemic stroke. The aim of this study was to evaluate the influence of early treatment with simvastatin, an HMG-CoA reductase inhibitor, on serum TNF-alpha level in acute ischemic stroke (AIS). Patients with AIS (n = 36)(More)
OBJECTIVES Oxidative stress plays an important role in ischemic stroke pathophysiology. Some drugs are known to have a substantial influence on oxidative stress. In this study, we examined the antioxidant effect of simvastatin through its influence on patients' serum 8-isoprostane levels. METHODS We measured serum 8-isoprostane levels in 67 patients with(More)
Our goal was to analyze the effects of treatment with a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (simvastatin, 40 mg/day) on serum S100BB and tau protein levels during the acute ischemic stroke (IS). Twenty four patients with IS were divided into two equal groups; treated and untreated with simvastatin. Blood was obtained four(More)
Like other proinflammatory cytokines, TNFmay play an important role in the development of central nervous system injury following ischemic stroke. The aim of this study was to evaluate the influence of early treatment with simvastatin, an HMG-CoA reductase inhibitor, on serum TNFlevel in acute ischemic stroke (AIS). Patients with AIS (n = 36) were randomly(More)
The aim of this study was to evaluate the plasma level changes of B-type natriuretic peptide (BNP), biochemical marker of heart failure, and echocardiographic parameters during mitoxantrone treatment in 22 multiple sclerosis (MS) patients (8 males, 14 females, mean age 37.1+/-6.6). Mitoxantrone (after mean cumulative dose of 58.0+/-7.0 mg/m(2)) did not(More)
The technical aspects of microemboli detection are summarised in this paper. The physical principles of the microembolus signals detection, their ultrasound characteristics, the possibility of identification of microembolus signals in Doppler spectral wave and advised equipment settings have been reviewed. Then the methods of automatic microemboli detection(More)
OBJECTIVES Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland. METHODS AND RESULTS We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data(More)
Activation of the complement system (C) is an important aspect of the immune reaction, and therefore also of inflammatory response. This review summarizes the known pathways for C activation, including the relatively recently described lectin pathway. We must remember that the complement, like the immune response itself, is a two-edge sword. One side is(More)