Anna Solé-Ribalta

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Sickle cell disease is an inherited monogenic disease. The most frequent form is due to a homozygous mutation in the S allele that encodes haemoglobin S. Its clinical course, while highly variable, is characterised by chronic haemolytic anaemia and vaso-occlusive events leading to early multiorgan failure. We present the case of a 7-month-old infant who was(More)
BACKGROUND The 13-valent pneumococcal conjugate vaccine (PCV13) was licensed based on the results of immunogenicity studies and correlates of protection derived from randomized clinical trials of the 7-valent conjugate pneumococcal vaccine. We assessed the vaccination effectiveness (VE) of the PCV13 in preventing invasive pneumococcal disease (IPD) in(More)
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