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Hypoxic non-small cell lung cancer (NSCLC) is dependent on Notch-1 signaling for survival. Targeting Notch-1 by means of γ-secretase inhibitors (GSI) proved effective in killing hypoxic NSCLC. Post-mortem analysis of GSI-treated, NSCLC-burdened mice suggested enhanced phosphorylation of 4E-BP1 at threonines 37/46 in hypoxic tumor tissues. In vitro(More)
  • Loyola eCommons, Anna Sobol, +8 authors Lucjan Sobol
  • 2015
AUGUST 2015 ACKNOWLEDGMENTS I would like to thank all of the people who helped me during my graduate work, starting with my mentor Dr. Maurizio Bocchetta. His passion for science, research experience, experimental ideas and mentorship made this dissertation possible. I would also like to thank my dissertation committee including: Dr. Dr. Maurizio Bocchetta.(More)
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